Particle size-dependent and surface charge-dependent biodistribution of gold nanoparticles after intravenous administration
نویسندگان
چکیده
منابع مشابه
Size-dependent cytotoxicity of gold nanoparticles.
Gold nanoparticles are widely used in biomedical imaging and diagnostic tests. Based on their established use in the laboratory and the chemical stability of Au(0), gold nanoparticles were expected to be safe. The recent literature, however, contains conflicting data regarding the cytotoxicity of gold nanoparticles. Against this background a systematic study of water-soluble gold nanoparticles ...
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Gold nanoparticles of different shapes and sizes, including nanospheres, nanocubes, nanobranches, nanorods, and nanobipyramids, were dispersed into water-glycerol mixtures of varying volume ratios to investigate the response of their surface plasmon peaks to the refractive index of the surrounding medium. The refractive index sensitivities and figures of merit were found to be dependent on both...
متن کاملProtein-coated pH-responsive gold nanoparticles: Microwave-assisted synthesis and surface charge-dependent anticancer activity
The biocompatibility and ease of functionalization of gold nanoparticles underlie significant potential in biotechnology and biomedicine. Eight different proteins were examined in the preparation of gold nanoparticles (AuNPs) in aqueous medium under microwave irradiation. Six of the proteins resulted in the formation of AuNPs. The intrinsic pH of the proteins played an important role in AuNPs w...
متن کاملSize-dependent LCST transitions of polymer-coated gold nanoparticles: cooperative aggregation and surface assembly.
Controlling the self-assembly of nanoparticles in higher-order structures and guiding their deposition in defi ned arrays on surfaces are key challenges in nanoscience and important e.g. for applications in diagnosis and sensing. [ 1 , 2 ] To make ever more complex nanosystems, it is desirable to control (or “trigger”) nanoparticle assembly upon application of a specifi c stimulus. Mirkin et al...
متن کاملSize-dependent in vivo toxicity of PEG-coated gold nanoparticles
BACKGROUND Gold nanoparticle toxicity research is currently leading towards the in vivo experiment. Most toxicology data show that the surface chemistry and physical dimensions of gold nanoparticles play an important role in toxicity. Here, we present the in vivo toxicity of 5, 10, 30, and 60 nm PEG-coated gold nanoparticles in mice. METHODS Animal survival, weight, hematology, morphology, or...
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ژورنال
عنوان ژورنال: European Journal of Pharmaceutics and Biopharmaceutics
سال: 2011
ISSN: 0939-6411
DOI: 10.1016/j.ejpb.2010.12.029